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Search Results for " nerve growth factor receptor "

Targets Recommended: Apoptosis Raf Trk receptor CDK

7

抑制剂 & 化合物

1

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6052	GW 441756	Apoptosis; Raf; Trk receptor; CDK	Apoptosis; Cell Cycle/Checkpoint; MAPK; Tyrosine Kinase/Adaptors
	GW 441756 是一种高特异性神经生长因子受体酪氨酸激酶 a 抑制剂，IC50值为 2 nM，可消除 BmK NSPK 诱导神经突生长。
T11861	LM11A-31 dihydrochloride	Others	Others
	LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T9272	Xaliproden hydrochloride	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Xaliproden hydrochloride 是选择性和具有口服活性的5-HT1A 受体激动剂，对大鼠海马中的 5-HT1A 特异性结合位点表现出高亲和力。它也是选择性的多巴胺D2受体拮抗剂，具有抗抑郁和抗焦虑作用，有用于神经退行性疾病的研究潜力。
T63346	TRK-IN-18
	TRK-IN-18 是 TRK 的有效抑制剂。其中原肌球蛋白相关激酶 (Trks) 是一种受体酪氨酸激酶家族，由神经营养因子激活，神经营养因子是一组可溶性生长因子，包含神经生长因子 (NGF)、脑源性神经营养因子 (BDNF) 和神经营养因子-3 (NT-3)，以及神经营养因子-4/5 (NT-4/5)。TRK-IN-18 表现出对癌症疾病的研究潜力。
T63965	Bepotastine tosylate
	Bepotastine tosylate 是一种选择性、口服具有活力的第二代组胺 H1 受体 (histamine H1 receptor) 拮抗剂，对组胺介导的神经生长因子 (NGF) 表达上调表现出抑制作用。Bepotastine tosylate 能够用于研究过敏性鼻炎，过敏性结膜炎和荨麻疹/瘙痒症。
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841)为针对神经生长因子(NGF)的犬单克隆抗体(mAb)，通过抑制NGF与肌球蛋白原受体激酶A(trkA)及p75神经营养蛋白受体(p75NTR)的相互作用，应用于犬骨关节炎疼痛的研究。
T62561	TRK-IN-17
	TRK-IN-17 是一种 TRK 的有效抑制剂。其中原肌球蛋白相关激酶 (Trks) 是受体酪氨酸激酶家族成员，由神经营养因子激活。神经营养因子是一组可溶性生长因子，包括神经生长因子 (NGF)、脑源性神经营养因子 (BDNF) 和神经营养因子-3 (NT-3)，以及神经营养因子-4/5 (NT-4/5)。TRK-IN-17 具有潜力进行癌症疾病的研究。

化合物

Cat.No: T6052

Target: Apoptosis, Raf, Trk receptor, CDK

LM11A-31 dihydrochloride

Cat.No: T11861

Target: Others

Xaliproden hydrochloride

Cat.No: T9272

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T63346

Bepotastine tosylate

Cat.No: T63965

Cat.No: T76813

Cat.No: T62561

Cat. No.	Product Name	Target	Signaling Pathways
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。

天然产物

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02614	NGFR/p75NTR Protein, Human, Recombinant (hFc) 神经生长因子,nerve growth factor re...	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is P08138.
TMPY-04646	NGFR/p75NTR Protein, Rabbit, Recombinant (His) 神经生长因子,nerve growth factor re...	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is XP_008269543.1.
TMPY-06959	NGFR/p75NTR Protein, Rat, Recombinant (His) 神经生长因子,nerve growth factor re...	Rat	HEK293 Cells
	NGFR/p75NTR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.34 kDa and the accession number is P07174.
TMPY-06973	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) nerve growth factor receptor<...	Cynomolgus	HEK293 Cells
	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.03 kDa and the accession number is XP_005583674.1.
TMPY-04831	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) NGFR,nerve growth factor rece...	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is XP_008269543.1.
TMPY-02541	NGFR/p75NTR Protein, Mouse, Recombinant (His) Tnfrsf16,神经生长因子,nerve growth factor	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Z0W1.
TMPY-02588	NGFR/p75NTR Protein, Mouse, Recombinant (hFc) p75NGFR,RP23-67E18.6,p75,p75NTR,LNGFR,神经生长因子,Tnfrsf16,ne...	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is Q9Z0W1.
TMPY-02615	NGFR/p75NTR Protein, Human, Recombinant (His) p75(NTR),TNFRSF16,神经生长因子,p75NTR,nerve growth	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is P08138.
TMPJ-01468	pro-Beta NGF Protein, Human, Recombinant β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth ...	Human	E. coli
	The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant BDNF,Abrineurin,Brain-Derived Neurotrophic Factor	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPK-00774	TrkA Protein, Human, Recombinant (aa 33-417, His) TrkAI,TrkA I,Trk-A,TRKA,NTRK1,MTC,TRK,TrkA-I	Human	HEK293 Cells
	TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects.

重组蛋白

NGFR/p75NTR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02614

Species: Human

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Rabbit, Recombinant (His)

Cat.No: TMPY-04646

Species: Rabbit

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Rat, Recombinant (His)

Cat.No: TMPY-06959

Species: Rat

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06973

Species: Cynomolgus

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)

Cat.No: TMPY-04831

Species: Rabbit

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02541

Species: Mouse

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02588

Species: Mouse

Expression System: HEK293 Cells

NGFR/p75NTR Protein, Human, Recombinant (His)

Cat.No: TMPY-02615

Species: Human

Expression System: HEK293 Cells

pro-Beta NGF Protein, Human, Recombinant

Cat.No: TMPJ-01468

Species: Human

Expression System: E. coli

BDNF Protein, Human/Murine/Rat, Recombinant

Cat.No: TMPJ-00135

Species: Human,Mouse,Rat

Expression System: E. coli

TrkA Protein, Human, Recombinant (aa 33-417, His)

Cat.No: TMPK-00774

Species: Human

Expression System: HEK293 Cells

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